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A clinical study involving 50 human subjects using 4% Syn-AKE topically twice daily for 28 days demonstrated[5]: Wrinkle depth reduction of up to 52% on forehead expression lines Smoothing effect measurable in 80% of participants Wrinkle reduction evident in 73% of subjects Superior efficacy compared to acetyl hexapeptide-8 (Argireline) in head-to-head comparison Skin surface measurement studies using profilometry showed improvements in skin roughness parameters (Ra, Rz, and Rt measurements), with effects visible as early as 1-2 hours post-application continuing through 28 days of use[5]

But it also doesnt have to hold you back

Nucleic Acids Res 48:e127 Yamada T, Tahara E, Kanke M, Kuwata K, Nishiyama T (2017) Drosophila Dalmatian combines Sororin and shugoshin roles in establishment and protection of cohesion

And he was my patient at that time

DEFINITION AND HISTORY Deficiencies in the activities of a number of erythrocyte enzymes may lead to shortening of the red cell life span